Paxil sedating

Paxil and wellbutrin and panic disorder...?

2020.11.25 18:00 Radtechmum90 Paxil and wellbutrin and panic disorder...?

New to posting but I'm looking for answers. I started paxil 7 weeks ago for panic and anxiety with underlying depression. Recently I was upped to 37.5mg paxil from 25mg. It helps a lot but made me feel more sedate, lazy, and hungry. I started 75mg sr wellbutrin once daily about 5 days ago to help combat the lazy and it has!! It has even lifted my spirits. Woke up today and had a panic episode and I recognized it and breathed through it and took a tiny dose of clonazepam to help the effects.
Does anyone have experience with panic and wellbutrin and if it gets better? I used to take lexapro but it gave me horrible heart palpitations and didn't really do much for anxiety. I'm also in therapy and using all my resources to try and combat anxiety or panic.
Thank you so much and sending love in this difficult time.
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2020.10.28 06:27 slushhee Wellbutrin, Paxil, or Rexulti?

Not asking for anything only a doctor is qualified to say, but I'm curious as to the medications that have worked best of the three listed for everyone here. My doctor gave me these three options at my last appointment, and I chose to start wellbutrin because I knew it wasn't an ssri and that it was also a weak stimulant. After some research I've seen conflicting statements between Paxil and Wellbutrin's chance for triggering mania.
The general consensus is that Paxil is less likely even though it is the most potent ssri, and that it has better chances for improvement for anxiety as well. Weight loss is also a big concern for me because I'm already skinny enough and could stand to gain a few pounds. I've taken lexapro in the past and it didn't do much for me until I combined it with wellbutrin, but that triggered a manic episode. Also, Wellbutrin has been giving me a lot of suicidal thoughts since I started taking it about 5 days ago, and I never had that problem with lexapro, so I'm really considering switching to Paxil. One extremely rare, but concerning side effect of Paxil is psychosis, and I've never had a psychotic episode nor do I want to have my first even though it feels like I've been heading that way for a long time.
The only benefit of wellbutrin so far has been increased focus, but I can't expect any benefits this early on.
The third option, Rexulti, looks promising for helping with depression, but I'm very concerned about taking antipsychotics because I've heard a lot about the cognitive decline and intense sedation thats associated with them, not to mention all of the negative effects there could be on my physical wellbeing. On the other hand, Rexulti is the only medication of the three that is FDA approved for bipolar depression, and is the least likely to cause a manic shift. My biggest fear of taking antipsychotics is the chance of losing my personality.
I'm very undecided on what the best choice for me would be because I don't want to trigger another destructive manic episode but I also don't want a lot of undesirable side effects. Can I get some anecdotes on your experiences with these drugs? Any help is greatly appreciated.
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2020.10.22 19:25 maltroniKs Paxil withdrawal

Hello friends! I am 33 and have been on paxil for 3 or 4 months and am attempting to cold turkey it because the sedation was ruining my life. I have done this before when I was like 17 and survived but have 0 memory of it. I am remaining on wellbutrin and lorizepam and vyvanse... what are some tips to help relieve symptoms of withdrawal and wish me luck
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2020.09.15 13:10 CuteBananaMuffin Mind Control - The Science of Drugs

As the reader can see, the use of drugs in the Monarch Trauma-based Mind Control is extensive and requires skilled technicians, nurses, and doctors.
Because of the long-held control by the Illuminati families over narcotics and drug manufacture/sales, there is no difficulty for the programmers to get large quantities of secret designer drugs. The minor occult cults have to get by with a more limited supply of mind altering drugs, unless they directly connect in with the bigger picture.
The power of drugs to control a person’s life is not absolute - although someone who lives with a cocaine addict or alcoholic might disagree - but when coupled with all the other methods in a sophisticated system of mind-control, drugs just further reinforce the absolute power of the Illuminati over an individual.
The science of Pharmacology (drugs) has given the Programmers a vast array of mind-altering and body-altering drugs. Some of the drugs are not used to directly alter the mind, but to change the body (makethe skin burn), or make the person vomit, or some other reaction that can be harnessed to further their nefarious programming goals. If they want a little girl to develop breasts they might give her hormones. Neuroscientists are now familiar with chemicals which cause personality traits.
If one wants to create raving paranoia, simply provide the brain with too much dopamine in the emotional centers of the brain and too little dopamine in the seat of reasoning area of the brain. Reduce serotonin in the person and the person will be unable to connect disagreeable consequences with what provoked them. In other words, they can’t protect themselves from danger.
Thorazine was used regularly at the CIA’s Jonestown, Guyana group control experiment. Survivors of Jonestown have testified as to its effectiveness. After this gruesome experiment in mind control came to its end with a massacre, large amounts of drugs were discovered. Just one footlocker at Jonestown alone contained 11,000 doses. The authorities prevented chemical autopsies of the bodies to insure secrecy of this sophisticated concentration camp which was used for medical and psychiatric experimentation by the CIA.
An examination of the drugs that are used in mental hospitals to alter the minds of patients offers a clear indication of what is being used in the Monarch Mind Control programming.
The CIA/Illuminati programming centers have more than 600-700 different drugs at their disposal.
The following is a partial list of the drugs available for their mind-control (aka MK-Ultra Programming). They can make a person feel like he is in heaven, or burning in hell. The drugs are at times used with elaborate light, sound and motion shows that produce whatever effect the programmer wants to produce.
They can make a person believe he is shrinking, or that he is double (with mirrors), or that he is dying. Before describing how drugs are used for programming & control, let us list a few which we know have been used. This list comes from CIA documents obtained from the Freedom of Information Act and from what Multiples used as Programmers remember.
Many of the new synthetic drugs are known only to the Illuminati/Intelligence community:
When the victim’s body is saturated with all the drugs they can assimilate, they will receive herbs, which often have a drug effect.
Religious groups, shamans, medicine men, witches and cults have been using mind altering drugs throughout history. The medieval witches used potions of hemlock and aconite for their flying ointments. These are herbs (natural drugs) which will create delirium. Contemporary witnesses reported that covens during the medieval ages would apply the potion of hemlock and aconite to cause their new witch to go delirious, and then would transport the person to the Sabbat, where they would be told they flew there.
The Haitian satanic Vodoun cult, which has been manipulated by the CIA/Illuminati, has sorcerers called bokors. The Vodoun cult in Haiti is being used for trauma-based mind control. One of the items of the cult is to take the plant Datura stramonium and add this plant with other things. The plant is the active ingredient of a potent psychoactive drug, the “zombi cucumber” which produces amnesia and a pseudo-death of the victim. The brain doesn’t die, but the mind is shut off.
The victim is brought back to life as a zombie--a slave of the bokor. The powder to create a zombi is called zombificant in French-creole. The ceremonies to kill and resurrect the zombie are full of magic and demonology also.
Magic, drugs and demonology have always gone hand in hand. Drugs remove the part of the will that prevents demonic possession. Drugs are considered powerful demonizing substances by the those skilled in Demonology. If demonic possession is seen as part of mind-control, then cocaine, hashish, crack, and some of the other drugs are part of the effort to enslave people. (The power of magic to kill, just as the power of faith can heal, will be discussed in chapter 10.)
In Basutoland in Drakersbergs, the Zulu witchdoctors use drugs and trauma to create tokoloshes (mind-controlled zombie slaves). It is said that in recent years, they are using less children and more baboons and monkeys to get tokoloshes. The point is that drugs have been and continue to be used by the occult world for controlling people.
The intelligence agencies working through the U.S. government financed drug research. An example is that Dr. Beecher of Harvard University was given via the U.S. Army Surgeon General’s Office $150,000 to investigate “the development and application of drugs which will aid in the establishment of psychological control.”
Research into drugs for mind-control began in 1947 at Bethesada Naval Hospital in Maryland. A CIA report described this research as to “isolate and synthesize pure drugs for use in effecting psychological entry and control of the individual.” At the California Medical Facility at Vacaville, Dr. Arthur Nugent, conducted research into drugs for mind control under the auspices of the CIA. The Bureau of Narcotics worked with the CIA to establish “safe houses” where drugs which were seized were given to victims. Some other hospitals which began working with the intelligence agencies with dispensing drugs for mind control include Mount Sinai Hospital, Boston Psychopathic Hospital, University of Illinois, University of Michigan, University of Minnesota, Valley Forge General Hospital, Detroit Psychopathic Clinic, Mayo Clinic, the National Institute of Health, and Letterman Hospital in the Presideo, CA.
The military did drug research/programming at the Army Chemical School in Ft. McClellan, AL and at the Edgewood Chemical Center. In 1958, Dr. Louis Gottschalk, working for the CIA suggested that addictive drugs be used to control people. Some GIs who became addicted to pain killing drugs were subsequently blackmailed by withholding the painkillers until they complied with the demands asked of them.
Cocaine has been frequently given to Monarch slaves to get them addicted and give their handlers more control over them. There is spray cocaine, and powdered cocaine, etc. Because the Monarch slaves are used to haul drugs and to launder the drug money, they are right in the middle of large supplies of drugs. If you hear the expression “The snow is falling” it is the Network’s lingo for cocaine.
Cocaine is reported to give people a feeling of power and to act as an aphrodisiac.
Drugs are used during programming. Although drugs used to assist programming mean nothing to the common person, they each have a specific purpose within a certain type of programming.
Some specific uses for drugs during programming include:
At this point, it is appropriate to point out that the personalities of a multiple do not respond uniformly to the same dose of the same drug. Understanding how a drug will effect particular alters is a science in itself. If an alter is holding the body, it will receive more of the effect of a drug. Let’s say Paraldehyde is given to a multiple.
A possible reaction would be that some alters will feel no effect, some will be sedated to a drunken stupor, and child alters may be unconscious or hyperactive. Chloral hydrate might put some alters to sleep while others remain wide awake. Sometimes the personality holding the body may fight the influence of a drug to keep the body.
Prochlorperazine is sometimes given by therapists to help alters cope with nausea and vomiting. Most alters will be programmed not to accept drugs except from their master. Lithium suppresses alter switching in some systems. An alter to “protect” the system from the therapist’s helpful medications may develop “allergic” responses. Alcohol is a drug. The reaction of an alter System to it will again be varied. Child alters may become unconscious, while the adult alters don’t even become inebriated by large quantities of hard liquor.
Within males, dangerous violent personalities may take the body. Within the medical world, often an approximate correct dosage will work. However, with the programming the doses must be extremely fine tuned. Some of the best skilled medical doctors and assistants help with the programming. The Illuminati will initially give the small child a small dose of a drug. They will chart its effect, give it a urinalysis to see how long it stays in the body etc. This is just the testing stage, they are not doing any programming. A number of drugs will be tested, but only one at a time. They clear a child’s body of a drug before they give it another one. They prefer not to mix meds. They will start small to insure they don’t overdose and then increase the dosage until they notice the correct behavior pattern. This will be charted in detail on the slave’s chart.
Each child’s body chemistry is different, so the suggested dosages are only ball park figures which are not precise enough. If too much of a drug is given, the programmers can easily turn a child into a psychotic basket case.
One of the secrets of the Illuminati/Intelligence agencies is that they have secret antidotes for most medications, which, if they have to give them to a child, then they will. They will use an antidote, for instance, to keep a child from going into heart failure. The Programmers will have some helpful drugs and herbs on stock too. It is reported that Glutamic Acid (1000 mg. 3 times/day) will take care of the intense headaches that alters get from lots of switching.
Witch hazel leaves and comfrey root will help internal bleeding.
Putting people into trance
About 90% of the population can be placed into the somnambulistic (the deepest) hypnotic trance possible simply by giving them hypnotic drugs. The prior list on pages 47-50 gives over 2 dozen drugs that can be used to assist taking someone in hypnotic trance. Special drugs have been designed which will place someone into a deep trance very quickly.
If an alter is not being cooperative when they are accessed, they can be locked in place mentally and given a quick shot of a fast-acting hypnotic-inducing drug. One drug which was popular for programming was demerol, which would be administered intravenously (an IV). It takes about 5-7 minutes to take full effect after administration via an I.V.
The dosage can be administered so that the effect remains until the programming session is over. It may be administered about every half hour if appropriate. Children will receive 1 to 2.2 mg/kg dose. Another drug, a truth serum, also consistently works on people making them totally compliant to any directive. Under Baradanga people will give their bank account numbers and anything else a person might want.
These type of drugs are almost sufficient in themselves to get compliance out of a person. If one realizes that these drugs are used in conjunction to torture, elaborate systems of lies and deception, trauma-bonds, and all the rest of the sciences of mind-control used in the programming, it is easy to see how they are producing totally compliant human robots.
Teaching alters to go deeper into trance to escape drug effects and pain
Much of the training in this area is based upon the child’s horror and fear toward the all powerful master programmer. When the programmer wants the child’s alters to learn to trance deeper, he will give a drug that the alter doesn’t like. The child’s alter will then be told to go deeper into the mind if they want to escape the effect of the drug.
This enforces the dissociative state being trained for the alter. The suggestion or story line that is given to the alter is frequently the picture of a train. The child is told that the conductor is at the front of the train, but he must move to the back of the train through the train cars. The child is taught to count cars when they go by as if they were steps in the mind.
This is training the child to descend into deeper levels of the subconscious. The train illustration has been used by programmers when they want the child to remember the drug experience. The programmer wants this experience remembered--at least for a while because it helps increase the child’s fear.
If the programmer wants the child to forget the drug experience while learning trance depths, then the imagery of a plane taking off and disappearing in the clouds works.
Enhancing the trauma
Drugs will be used to enhance the spinning effect when the mind is being programmed to have vortexes and to set up traps within the slave’s mind. One particular drug enhances the trauma by 100 times.
Drugs can be useful for instance, to enhance a child’s terror of the experience of this child being placed in a small box in the fetal position for 24 hours. This helps shorten the programming time, and it also makes the programming more intense. The programmers know what antidotes to give to pull the child out of the enhancement. Marijuana enhances perception of color and noise, but it is not used to enhance trauma.
The mind does not program well under marijuana. That is why there has been such a big campaign to keep it illegal, even though many studies show it to be safer than alcohol.
Producing out of body experiences
Various hallucinogenic drugs, LSD included, will produce an out of body experience for the victim, if the drugs are administered correctly. The Programmer will prepare the victim with various information and story lines during the administration of the drug. Monarch slaves are being deprogrammed, they may have a memory where their skin feels inflamed and itchy, like a bad mosquito bite.
The experience may also have the sensation of floating in an unreal world. This may well be an LSD trip given the slave during experimentation and programming. The CIA was using LSD beginning in the very early part of the 1950s. Several victims report that some type of potion causes a person to dream while they are awake.
PCP which is “angel dust” is one way to disconnect the cortex from the limbic system and go into an altered state.
Creating pain
This is done with a long list of drugs. Drops of salt water and pepper water are applied to the eyes of victims to make their eyes sting. Another pain in the eye takes place when lights are flashed signalling, “I love you, I love you not.” The child is pulled two ways by this message.
Dr. Green (Mengele) enjoyed pulling daisy petals while saying these words. If the last petal was “I love you not,” the child would be put to death. Surviving children were left traumatized.
Creating blood vessels that hurt
Blood pressure is raised by drugs and then certain drugs are added which make the veins burn. The alter is taught to cut the burning veins. This is programming which is laid in to control the slave from straying from the script he or she is given.
If they stray, then a cutting program is activated which was laid in via a combination of drugs in the method just stated.
Controlling histamine production
The control of histamine production is an important secret ingredient to the Monarch Mind Control. The breast implants placed into women help stimulate histamine production, which is used in conjunction with drug-assisted programming (See Chapter 8.)
Helping create illusions such as no hands, no feet, no face, no head etc
A programmer working with a hallucinogenic drug can make an alter believe that it has lost a particular body part. Because most of these alters have little memory or no memory and little frame of reference, what they are told while under the influence of drugs seems very real to them.
Teaching alters to stay in position
Some alters don’t like to stay in position. But through the use of drugs, and the side effect of drugs, they soon learn the importance of staying in position. If they are disobedient, the memory of the bad side effects from not staying in position in the mind can be pulled up by a code and the alter can relive the pain from having disobediently moved from position.
This is very effective in teaching alters to stay in their little position that is assigned them in the mind.
To assist other programming modalities, such as high tech harmonic machines, which implant thoughts. (The machines are used in conjunction with designer drugs.) An example of how drugs can be important is as follows. The neurons in the hippocampus which is part of the memory process use acetylcholine.
Drugs that block acetylcholine interfere with memory. The neurons and the chemical neural transmitters are understood much better today. Where and how a thought is created in the brain is understood by the programmers in detail. No one is in a position to physically prevent the Illuminati and others from taking their children and others to labs where chemicals and harmonics can be used in sophisticated computer guided ways to implant thoughts into the children’s minds. As the child’s brain is shaped according to its environment, the level of everyday brain chemicals and the shape of the various areas of the brain can be determined by the programmers.
This is why a recent article on Prozac (Newsweek, Feb. 7, 1994) uses a quote from Alice In Wonderland for its title, “One pill makes you larger, and one pill makes you small”.
This article (on page 38) quotes brain researcher Restak,
“For the first time, we will be in a position to design our own brain.” On the previous page in big letters it reads, “Scientific insights into the brain are raising the prospect of made-to-order, off-the-shelf personalities.”
Another programming modality assisted by drugs is behavior modification. Aversion therapy using a vomit-inducing drug is used on children. Another example of drugs helping assist programming is to give someone LSD and then interview the child while it is hallucinating.
The hallucinations are then used as programming building blocks by using hypnotic techniques. One way to build on a LSD trip is to tell the child if they ever do a particular thing (such as touch programming, remember programming, and integrate parts, etc.) the victim is to go crazy and hallucinate like they are presently doing. This means that they will be locked up in a crazy house for the rest of their life.
Rather than be put in straight-jackets with other crazy people it would be better for the person to commit suicide. By constantly reinforcing this message, some alters will adopt the script “that they are doing the body good to kill it if any alter personality touches the programming,” because otherwise the body will be locked up in a crazy house.
Drugs are used in programming to establish a pattern or a script. There must be a pattern of dissociation. Parts can’t just dissociate into nothing, otherwise there would be nothing to build on. Drugs will play a major role in the structuring of the alter system, which is covered in chapter 7.
The child doesn’t know where the effect of the drug is coming from. The programmer will take credit for the power of the drug. Whoever administers the drug has power in the child’s mind. The mind wants to be safe. I am familiar with a recent example here in Oregon of someone who escaped from being sacrificed at a Satanic Ritual.
The legal system told the woman she was crazy when she reported to the police that she had escaped from a Satanic Ritual where they were going to sacrifice her. To control her, the judge ordered 3 types of antipsychotics, twice the normal dose of two kinds of lithium carbonate to put her into a lethargic stupor, Paxil as an antidepressant, and Benztropine mesylate as an antiparkinsonian agent. The antipsychotics were Thiothixene, Thioridazine hydrochloride, and Perphenazine which are all addictive.
This woman may or may not be a multiple. But this clearly shows the type of mental control via drugs that could be slapped onto someone who dares report Satanic activity to an establishment which has been sadly corrupted from top to bottom. One victim of government mind control tried to get free. The first psychiatrist the person tried to go to was cooperating with U.S. Intelligence and gave her Stelazine, which aggravated the victim’s situation.
When the victim spied a general’s uniform in the closet of this psychiatrist, she got another psychiatrist, who unfortunately turned out to be an ex-DoD employee. He placed her on Haldol Decanoate, Klonopin, and Benzatropine. The combined effect of these drugs is to erase memory, and create a dissociative disorder.
All of the drugs were highly addicted. Another fleeing victim was given Trazodone by a physician who was cooperating with the Intelligence agencies. This almost gave the victim a heart attack because it aggravated her heart condition. And yet another escaping victim apparently also fell prey to dirty CIA doctors who were practicing in public without warning people of their intelligence connections.
This victim was given a combination of Compazine and Xanax, in dosages that the Physicians Desk Reference warns against. The doctor, who prescribed this, worked out of an office named after an MK Ultra programmer. There are other important things to mention about when drugs are used in Monarch programming.
Some of the cautions that the programmers are alert to include:
a. watching the heart so that it doesn’t stop. Many of the children who have been programmed have died from heart failure. The programmers are very careful to have heart monitors on the victim, and to have paddles ready to revive the body. Because so much of their drugging affects the heart, they accept that they will lose a few to heart failure.
b. making sure that drugs aren’t given to children who are allergic to them. The programmers take the time to insure that they have the family histories of allergies to drugs, and they will test the children too, before proceeding with drugs. They not only learn the family & individual responses to drugs, but they can test during programming to determine a drug’s blood level in a child. For instance, pentobarbital at a blood level of 5 mcg/ml aids hypnosis, at 15 makes the victim comatose with reflexes, and at 30 makes the person comatose w/ extreme difficulty in breathing. In everyday life, 30 mcg/ml would kill the child. Pentobarbital blood levels can be tested by an enzyme multiplied immunoassay technique. For longer-acting Phenobarbital gas chromatography is used. TCA’s are tested by radioimmunoassay, high-perf. liquid chromatography & thin layer chromatography. Some hypnotics are tested by colorimetry, photometry, & spectrophotometry.
c. switching to herbs when the body is saturated with drugs. When the child’s body has had all the manufactured drugs it can absorb, the programmers switch to a vast collection of natural herbs.
d. providing the antidote for AIDS. Monarch slaves are routinely given the antidote for AIDS and have been since the 1960s-1970s.
e. knowing how much of a drug each part can take, small young alters can’t take as much. Multiples within a single system have varying levels of tolerance toward drugs. A small child alter may be killed by an adult dosage, even though the age of the body is that of an adult. The programmers are acutely aware of how to deal with multiple personalities.
f. providing salt to balance the electrolytes in the mind of a programmed multiple personality. An electrolyte imbalance can cause a multiple personality’s mind to go wacky and start spinning. The Multiple could possibly go into shock and die. The programmers are very experienced in understanding the unique requirements of a multiple personality.
g. An important plant extract for watching brain wave activity is the large plant enzyme horseradish peroxidase (HRP).
Perhaps it would be worthwhile to briefly mention that all the major chemical and drug companies are run by the Illuminati.
It would take a book to explain who controls what and how they connect in, and this author could write it. Instead, we will try to give a quick over view. Rather than cover 2 dozen large drug companies, three major drug companies have been randomly selected to show a quick view of how all the drug companies are deeply involved with Monarch mind-control programming.
Since the purpose of this book is to show how the mind control is done--this sample of names is given only to convey to the reader that the drugs that the Illuminati/Intelligence agencies need are never in short supply.
And the labs to develop designer drugs for mind-control are not in short supply either.
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2020.09.10 05:12 medditthrowaway16b Patient death from Serotonin Syndrome vs. Prolonged QT?

PGY-1 here trying to process the death of a patient I've taken care of for weeks on my medicine service. Obviously this post is coming from a place of guilt, shame and sadness but a small part of me is trying to learn and also hear if other psychiatrists have experience with this situation.

Admitted a pt 70+ yo presenting to ED with these diffuse myoclonic jerks, worsening falls and increased confusion. Stopped their home Paxil 30 mg, Trazodone (forgot dose, for sleep), Mirtazapine 7.5 mg because I was concerned this was some serotonergic activation as some side effect of patient's poor kidney function. PMHx of COPD on 3 L O2, HF (30-35% on TTE), CAD with CABG, MVR with valve replacement, LGIB. Attending wasn't really impressed with serotonin syndrome since patient was hemodynamically stable so Paxil was resumed and instead diuresed because pt "appeared" overloaded but turns out they were just cachectic so veins were bulging, legs looked puffy-ish over legs and pt had prior hx of these shakes which improved with diuresing and DC dx was "uremic encephalopathy". Nephro finally consulted after BUN shot up and turns out pt overdiuresed and after hydration.... the jerks improved. Trazodone and mirtazapine restarted, baseline EKG was 500's after all their home psych meds back on. They went for EGD to assess GI bleed and then were transferred to ICU after not waking up from sedation after a couple hrs, likely because pt chronic hypercapnic with resp acidosis (bicarb in 40's). Transferred back to my care after a day, I come back after a golden weekend and shakes are worse, pt delirious/hallucinating, Mirtazapine and Trazodone DCed but Paxil still on board. Psych was consulted over weekend, recommended Olanzapine 5 mg after EKG QTc of 500. The day I came back pt got Paxil in AM (which I DCed in the afternoon after reviewing the weekend events but pt already got AM dose) and on exam pt was hyperreflexic (senior said this was from delirium), aggitated, delirious, hallucinating. No fever, no autonomic instability. Psych recommended Olanzapine 2.5 mg PRN given in evening and then it was given again at 1:30. BP's after I left were decreased, in 90's/60's, no fever, no notes of diaphoresis. Pt not on tele, sitter in room, was apparently sleeping throughout night when it was noticed they weren't breathing/alive? and pronounced dead 4:30.

So there was a lot of polypharm going on here, I didn't order an EKG again the day I got back (how often should I get EKGs?), pt has a lot of comorbidities.... any thoughts on what happened?
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2020.09.03 02:51 knightofgod_02 Advice Please

During the very beginning of the pandemic, I was on 20mg of Paxil. I did not report to work and was home in my thoughts for awhile. Anxiety, depression, irritability and no sex drive ran rampid. My PCP decided to take me off Paxil and put my on Buspar. This did not help at all and I was soon put on 5mg of Lexapro. Symptoms dis not improve and I found a new doctor with a different health network. I was put on 10mg of Lexapro and Serroquil. I was only able to take being on Serroquil for 2 days before I had to stop. This doctor ordered blood work as well. Symptoms again didnt improve and I went to a different highly recommended PCP. She started me on 30mg Cymbalta, which was soon upped to 40mg. It was also discovered my testosterone was low and was reffered to Endocrinology. This doctor put me on 4 pumps daily on Androgel. The depression mixed with anxiety has been especially bad the past 2 months. I had to call out of work several times because the depression entirely took over and I was not able to get out of bed. I have since been seen by Psychiatry. The Cymbalta was no longer working for me and I was put on 50mg of Zoloft and 20mg Cymbalta. The initial game plan was to ween off the Cymbalta after a week, however Psychiatry told me to continue both while I continue treatment with Endocrinology. After day 2 or 3 being upped from 2 pumps of Androgel to 4, as well as being on the Zoloft and Cymbalta I felt horrible driving into work. I felt heavily sedated and nauseous. I attempted to get into contact with Psychiatry, however was unable this day. I decided to stop taking the Cymbalta, as I felt it was too much. I have been on 50mg of Zoloft for about 2 weeks now. I have made an appointment with a new psychiatrist for several reasons. Its been an especially rough year and hopefully Endocrinology/Psychiatry can figure out treatment to have me feeling better. I have not yet been screened for bi-polar. I have had several severe mood changes as well. If you made it this far, thank you for taking time to read all this. Any advice would be greatly appreciated!
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2020.07.14 16:06 MinnesotaLuke Food Triggering Hypomania??

Hi everyone -
24 to 60 hours ago, I ate very bad. Not on purpose, it was just there. Lots of pizza, ice cream, pasta salad, etc. I'm pretty sure my stomach reacts terribly to wheat and dairy anyway buuuut -
Since getting off of my medication (Paxil for 10 years, which generally SSRIs are not good for bipolar but this was so sedating that it made me feel decent usually) - I have had very severe reactions to eating foods that before mainly before only gave me terrible stomach aches.
*This is NOT like where you feel crappy after eating bad... everything seems to be level 10 terrible*
For example, after this most recent 2 days of terrible eating, my ENTIRE day yesterday was:- Non stop agitation and irritability. Everything bothers me to level 100. I can hardly function. Only sleeping, porn, eating (lol), and a few other things can get rid of this. It sometimes goes away for a few minutes, but returns.- Severe anxiety and constant feeling of panic attack
- Sweaty hands / heart pounding
- Needing to talk fast or having racing thoughts
- Terrible stomach pain.
Thanks :(
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2020.06.22 04:39 coffeecandle10 Are my meds combination safe?

I have been on paxil 20 mg for a couple years. Just a week ago I was prescribed gabapentin 200 mg for occipital neuralgia. It helps a lot w the pain and suicidal thoughts.
Now, later this week I am going to be evaulated for mmj prescription to help with the pain too. I will request lightest dose if possible. But...i am short of breath sometimes from the gabapentin kicking in.
Are all these three nervous system drugs going to sedate me so much I'm gonna stop breathing? Kind of scared I'm over sedating but tired of living w the unmedicated pain.
submitted by coffeecandle10 to gabagoodness [link] [comments]

2020.05.30 15:19 lavloves I need a medication for my severe anxiety,

Before I was diagnosed with Bipolar 2, I had been on Effexor, Paxil, and Celexa. All of which I did NOT do well with. Paxil and Effexor did essentially the same thing to me, I was like a zombie and all I did was sleep, I couldn’t wake up, I missed alarms, the withdrawal was TERRIBLE. I tried Celexa very briefly, because it nearly had me in a psychosis state and I quickly got myself off of that.
Since I’ve been diagnosed, I’ve been on a mixture of Wellbutrin and Lamictal, which was fine for a while but I did have a bit of anxiety. Well, in the past few months, I’m convinced it’s doing nothing, if not the opposite of what it’s supposed to do for me. it’s been really bad. I can’t leave my house nearly, I’ve called in several times out of work because I’m just freaking out. I’m having panic attacks at work, just driving sometimes I get panic attacks. It’s turning into severe depression, and I’m pretty sure I’ve got a stomach ulcer coming on.
I’m not able to see my psychiatrist until the 15th of June. I’m thinking about just having my regular doctor put me on something. But I don’t know what... I don’t know that SSRIs will do me any good, which I’m sure is what he will first think of to put me on. Do all SSRIS work the same? Or is there a possibility that one could work for me? I hated Effexor and Paxil, but one thing they did do was completely wipe out my anxiety. I can’t really do Xanax or a sedative because I can’t just take one while I’m at work, I work in the medical field so that’s a huge no no. I’m not even worried about my bipolar disorder right now, the main goal is to chill out some of this anxiety, I can’t do this anymore. I’m tired of living like this.
submitted by lavloves to bipolar2 [link] [comments]

2020.05.30 15:17 lavloves Needing a medication for anxiety?

Before I was diagnosed with Bipolar 2, I had been on Effexor, Paxil, and Celexa. All of which I did NOT do well with. Paxil and Effexor did essentially the same thing to me, I was like a zombie and all I did was sleep, I couldn’t wake up, I missed alarms, the withdrawal was TERRIBLE. I tried Celexa very briefly, because it nearly had me in a psychosis state and I quickly got myself off of that.
Since I’ve been diagnosed, I’ve been on a mixture of Wellbutrin and Lamictal, which was fine for a while but I did have a bit of anxiety. Well, in the past few months, I’m convinced it’s doing nothing, if not the opposite of what it’s supposed to do for me. it’s been really bad. I can’t leave my house nearly, I’ve called in several times out of work because I’m just freaking out. I’m having panic attacks at work, just driving sometimes I get panic attacks. It’s turning into severe depression, and I’m pretty sure I’ve got a stomach ulcer coming on.
I’m not able to see my psychiatrist until the 15th of June. I’m thinking about just having my regular doctor put me on something. But I don’t know what... I don’t know that SSRIs will do me any good, which I’m sure is what he will first think of to put me on. Do all SSRIS work the same? Or is there a possibility that one could work for me? I hated Effexor and Paxil, but one thing they did do was completely wipe out my anxiety. I can’t really do Xanax or a sedative because I can’t just take one while I’m at work, I work in the medical field so that’s a huge no no. I’m not even worried about my bipolar disorder right now, the main goal is to chill out some of this anxiety, I can’t do this anymore. I’m tired of living like this.
submitted by lavloves to bipolar [link] [comments]

2020.05.23 22:38 KillDaCircle CBD Suggestions

I'm looking to possibly start a formal routine with CBD to treat mild symptoms of PTSD and stress etc.
What I'm looking for is suggestions that are reasonable and affordable. I used to take 10mg of Paxil and now that I've been off for about 2.5 months I recognize how powerful even a low dosage was as a sedative, although I do enjoy being free from the use of pharmaceuticals. I enjoy much richer emotional experiences ever since.
Any suggestions for the best quality vs. quantity or dosage so that I could reasonably use daily such as an oil tincture without an extreme monthly cost? I'm wondering how much I'd need to take and how often so that it could work to be somewhat sedative and calming, as a general treatment, and to enhance quality of life.
submitted by KillDaCircle to CBD [link] [comments]

2020.04.04 11:00 mad_rose4 I think my psychiatrist is a bully?

is all psychiatrists solution to sedate their patients or is that just me and bad luck? like they assume what you’re feeling or going through but don’t really care to ask questions and when you try to explain they jump to the easiest explanation...
My first (and only) 5150/5250 was because an MD put me on Lithium, Latuda, Zyprexa, Gabapentin and more all at once then stopped all of them no taper down. I was then started on high doses of Fluoxetine then Paxil. This all in under a year. the radical detox from Paxil took tolls on my body and mind and landed me in the psych hospital. Flash forward to the present after a bad experience now I have PTSD too. I dissociate 10 times more than I used to and way harder than I did before and I used to have anxiety but now I have panic attacks. My BPD symptoms are all through the roof even new ones are surfacing I didn’t exhibit before. My psychiatrist wants to put me on Prazosin for night terrors and sure okay but she’s pushing I start Serroquel and that’s an antipsychotic like lithium and latuda but plus it has major sedative effects. I think she’s convinced i’m psychotic but won’t say they diagnosis for the medication (which... haha is that legal?). I’m telling her it’s just dissociation plus the fear of that feeling on top of it causing I panic... and she’s treating me like i’m a kid and won’t listen to me telling me to take the drugs anyways and see how I feel. I don’t wanna go down that scary road of antipsychotics again where I can’t even function but I feel like she’s shoving it down my throat and not giving me another option like i’ll just have to suffer through all my heightened BPD symptoms plus now PTSD. by the way I’m not bipolar or schizo-effective so I don’t know why they’re trying to prescribe antipsychotics... also isn’t BPD mainly treated by DBT not drugs anyways? ugh what is she doin’? these are HEAVY meds they shouldn’t be prescribed so carelessly... and that’s coming from a licensed nurse (aka me) Please just do your research into what you’re taking they don’t always know what’s best.
submitted by mad_rose4 to BPD [link] [comments]

2020.03.05 20:49 octopusinahat For those that didn't respond well to first line anxiety and depression medications - would you share your experience if you found medication(s) that worked well for you?

TLDR: For those diagnosed with CPTSD and first line anxiety and depression treatments (mainly SSRI/SSNRI) did not help, have you found a medication regiment such as atypical antidepressants, anti psychotics, or other medications taken off label that have have helped your anxiety and depression?
I have a wonderful psychiatrist and an amazing therapist who have both really helped me make positive progress over the past few years but find myself still struggling in many ways so I decided to give meds a try. I briefly tried in the past but honestly didn't give them a fair shake. Over the past two years, I have had a rough ride with finding a medication regiment that has worked for me. I currently take Wellbutrin XL 150mg and Vyvanse 40mg (taken during the workweek).
In our last meeting, my psychiatrist and I agreed that SSRI's and SNRI's were not the approach for me and it was time to look at other options. I find that I tend to dissociate more when taking these medications. Others have been too sedating and impact my cognition even at low doses. I have done a lot of reading and it seems many of us folks with CPTSD don't respond as well to medications and maybe through this, just find that medication isn't a good choice for me.
I am currently tapering from my last SSRI and meeting with my psychiatrist in two weeks to continue our conversation about other medication options. While I know medication response is very much individual, I thought it may be helpful to hear what others experiences were.
Previous medications: Paxil, Lexapro, Effexor at vayring doses (low was best but still dissociate and just don't feel present in the world). Lamotrigine (no positive effects). Remeron (too sedating even at higher doses). I have tried increasing my Wellbutrin to 300mg but find it worsens my anxiety.
Thanks for your sharing your thoughts!
submitted by octopusinahat to CPTSD [link] [comments]

2020.02.25 01:06 SmokyLavender Anybody else out there dealing with Bipolar and Pre-Menstrual Exacerbation?

I got my BP2 diagnosis in 2016/2017 and i've found little to no relief since then.
A long journey with meds with little success and a recent major depressive episode has lead me to take leave from work, fly home, and ween off all my meds to find my baseline and start again now that i know how big of an impact Pre-Menstrual Exacerbation plays in my mood disorder. Looking for recommendations, support, advice, hope, dreams, etc.

Went through one bad psychiatrist before finding a good doc. Since then, I've been on over a dozen medications in countless combinations with nearly every side effect on the bottle. i seem to be the one in a million where if it can go wrong, it will. to add to this, my bp2 is greatly effected by my 21 day menstrual cycle (norm is 28, for those who dont know). I have about 10 days of intense irritability and mood swings before hand so, yup. thats about half my life where i feel totally out of control and basically just isolate myself to "protect" the world from me. I can usually manage to crawl out of my rage hole just in time for the next rage cycle to begin. it's exhausting and infuriating.
For the record, ive always taken a combination of a mood stabilizer such as trileptal or lamictal with an ssri added on (zoloft, wellbutril, stratera, paxil, etc). plus xanax for panic episodes. I also self medicate with weed, mostly in the evenings to shut my brain down but use has increased with my depression. I have a med card so my product is at least consistent.
Nothing works. Nothing helps. Not for more than a few weeks at best...usually until my next period. Trileptal did a pretty good job of controlling the swings but left me so sedated all i did was sleep and watch tv. Lamictal put more pep in my step but cant quell the pms rage. Paxil raised the whole bar a bit but still there's been this baseline of melancholy that has never really subsided. Most recently this sent me into a hell of a tail spin leading me to take leave from work and fly home to my parents' house to taper off all meds under their supervision (doc approved btw). The idea is this: before i knew they exacerbated mood disorders, i took hormonal birth control from ages 15-23. I had an iud when i started treating my bipolar and had it removed within a year or starting pych meds. So i have not known myself without pharmaceuticals since i was a teenager. the idea is to get a better idea of what my baseline is and IF i want to bring back meds, ill at least have a better idea of what im dealing with.
So, as i write this from my childhood bedroom (ugh, right?), im honestly terrified. what if i go through all this discomfort and effort and hell of withdrawal and i still have no answers? sometimes i feel like im making it all up. that i should just get over it. so not everyone gets to feel happy or cheerful, so what?
So I guess what im looking for is support. Have any of you had such a difficult journey with meds? Is anybody else dealing with PME on top of their bipolar? Did you ever find something that helped you?
submitted by SmokyLavender to bipolar2 [link] [comments]

2020.02.21 20:39 Fittybit Brain neurotransmitters and PE and my experience with medications

Hi there
I don’t usually go on this forum but I thought I should post my story in case it helps anyone. I’m writing this as a guide of some sorts for people who:
I do not recommend medications if you’ve recently developed PE without a previous history, this must be investigated by a doctor as it could be due to a multitude of factors (hormonal, vascular, mechanical, psychological..etc).
I’ve had PE since my very first sexual encounter, and I’ve never lasted more than 20-30 seconds. A few years ago I was placed on an SSRI for anxiety and it actually helped my PE. So I began the process of researching these meds and finding the right one/balance for me. I’ve had a normal sex life since then. I am a young doctor myself so It was natural for me to search for medications for my issue. Here’s what I’ve come to find out through this journey.
Selective serotonin reuptake inhibitors (SSRIs) are antidepressant/anti anxiety medications that can prolong time to ejaculation. Studies have shown that Paxil (paroxetine) has the best effect, followed by lexapro (escitalopram) and other types of SSRIs or SNRI. Tricyclic antidepressants (TCAs) can also do this, but they have many more side effects and are generally not necessary to try. The same goes for most other psychiatric medications, due to their serotonin effects.
Through the different medications trials I’ve personally had I’ve found that medications that effect dopamine tend to speed up time to ejaculation, and intensify orgasms. Wellbutrin (bupropion) is a classic example, and it’s actually given to HELP with “sexual dysfunction” due to SSRIs in people without PE. To speed up ejaculation time. Another class is ADHD medications, specifically stimulants (both amphetamine and methylphenidate compounds). Medications with norepinephrine can cause erectile dysfunction as it can cause vascular constriction. Wellbutrin is such a medication. But not everyone gets that side effects.
Not everyone responds to the same medications the same way.
Different metabolic profiles definitely play a role, as some people use up the medications faster than others. Also MANY psychiatric medications also have SOME serotonergic, dopaminergic, or adrenergic effects that are not their main targets, these are called side effects. For example, some SSRIs (like sertraline or Zoloft) or SNRIs (venlafaxine, duloxetine) have dopaminergic effects at higher doses. And I think it’s why they don’t help with PE (they’ve been studied for it).
I’ve said all this to say that if you choose to pursue medications, you may have to be patient and try multiple medications, at varying dosages, to find the right regimen for your body. Here is my personal experience with the ones I’ve tried:
Zoloft: barely helped with PE, caused some erectile dysfunction. These effects did not change with the dosages I’ve tried (up to 100mg).
Paxil: Significantly improves my PE even at very low doses. Very minimal effect on erections. At 20mg+, I was not be able to have an orgasm during sex at all. Quit it because of excessive sedation.
Wellbutrin: caused erectile dysfunction, worsened PE, intensified orgasms.
Lexapro: Significantly helped with PE. When taking 10mg at 8am. I could not orgasm during sex within the first 2 hours (when the medication concentration is highest in the body). But after, I’d last 5-10 min on the first round. And much longer on a second round. No side effects. I still take this once a day.
I’ve also tried finasteride, for hair loss. It actually also helped significantly with PE at 1mg. But, some people report decreased libido, because the medication blocks DHT.
Psychiatric medications can have many side effects depending on the person. I’ve not listed them here as they can be found online. One effect in particular is on mood, as some people report “flattening” of their mood or personality. However ALL these effects are dose dependent and, more importantly, reversible. Therefore, if you experience them, you can always stop the medication and return to normal. This applies to their effect on PE as well. These medications are not a cure. They would be taken daily. I’ve personally accepted that and I just take them in the morning and go about my day.
I hope this helps. I’ve tried not to make this too long. Happy to answer any questions.
submitted by Fittybit to PrematureEjaculation [link] [comments]

2020.02.19 20:23 sweggersmeg Paxil (paroxetine) 20MG

I’m confused as to which time of day I should take My Paxil 20MG. On the paper when they give you the information it says take it in the morning, but my doctor says to take it right before bed because it’s supposedly slightly sedating. Is that true? Does anyone who work with medication or knows anything about it know which time of day to take my Paxil? I want go get the most out of it and medicate properly. Thank you in advance!
submitted by sweggersmeg to antidepressants [link] [comments]

2020.01.26 08:53 PSSD_Kara Women, Sex and Antidepressants (Post SSRI Sexual Dysfunction)

The Pill That Kills Your Sex Drive
Antidepressants are everywhere. So are their dire effects on love and sex. Isn't that depressing?
By Paul John Scott - Apr 25, 2014
Katherine Sharpe will never know what caused her first serious relationship to end. And that still bugs her. What she does know is that over time, her physical desire for the man she dated in college began to wither. And as she points out, "sex inside a stable relationship is sometimes the glue that holds people together." She also admits that the flame could have gone out on its own. But there's another reason the love affair may have hit the skids, says the 34-year-old, and it doesn't sit quite so well. Its fate could have been sealed by a prescription medication she never really needed in the first place.
"The drug definitely diminished my interest in sex," says Sharpe, the author of Coming of Age on Zoloft. She was given antidepressants after a visit to the campus health center to talk about her anxiety, an ordinary window of distress she now views as minor. "I'll never know what role the drug played," she says, clearly wrestling with the thought. "I don't like having to wonder that. We went out for two years—a long time when you're 18. He was my first lover; we were crazy about each other. I wish I could be certain it failed entirely on its own merits."
I've had the same problem. When I was on Zoloft for two years in my early 30s, sex became like a footrace in snowmobile boots. The drug eased my anxieties during the day but jumpstarted them in bed. Those are well-known side effects, but it turns out that delayed orgasm and losing that itch are only two of the many ways antidepressants can handicap romance. These drugs do their work in the brain, which is why they can influence not just erections but also affection, connection, love, and attachment. That can leave you wondering if your lover's indifference derives from her heart, her head, her med, or a jumble of all three.
We live in the age of the foursome: you, her, and your respective pharmacists. With mood meds, a veritable rite of passage for many born after, say, 1980, large portions of the dating pool have known only pharmacologically influenced sex. Many are inserting meds into functioning but difficult relationships with no idea of the cost. Still others may be feeling effects that lingered after the drugs left their system.
This isn't a diatribe against mood-lifting drugs. People take them for good reasons. If your girlfriend is trying to pull herself together, it's a sign of maturity to seek help. If you want to tackle your problems without getting lost in work, partying, sex, or designer vodka, it's a sign of courage. But the generational legacy of our love affair with antidepressants is only now becoming apparent, and the "side effects" of these drugs may include everything from widespread singledom to the soul-destroying excesses of hookup culture to porn addiction to the problems of too many friends offering too many benefits.
With so many new unknowns, it pays to learn what antidepressants can mean for your ability to love another person, and how you show those feelings in the bedroom. Is it a happy pill, or something else?
Starting in the 1990s, a new generation of antidepressants were more aggressively marketed to a broader population. The main and most successful target group of these campaigns: women. According to data from the National Health and Nutrition Examination Survey, women are 2 1/2 times as likely to take antidepressants as men are. And with 264 million antidepressant prescriptions written in 2011, the selective serotonin reuptake inhibitors (SSRIs)—including Celexa, Zoloft, Prozac, and Lexapro—are some of the most prescribed pharmaceuticals in the nation. That means if your girlfriend is taking something from a brown bottle, chances are it's for her head.
College kids are presumably a peak demographic. Audrey Bahrick, Ph.D., a researcher on the sexual side effects of SSRIs and a staff psychologist at the University of Iowa's counseling service, says 20 to 30 percent of students coming to the service are already taking psychotropic meds. "Another 20 percent choose to start medication during the course of therapy, so of the college students seeking help, about 50 percent are on a psychotropic medication."
How do these meds work? SSRIs increase the availability of serotonin, but whether raising serotonin is the reason for the drugs' effectiveness is unclear. (Contrary to the marketing claim, depressed people do not have a "chemical imbalance" of low serotonin.) The drugs' effectiveness could be due to the placebo effect, or to mild sedating effects, or to mild mental energizing properties. But the bigger question is this: What are the drugs better at—improving depression scores or disrupting sexual function?
Research finds that only about half of patients respond to antidepressant treatment, and even among those who benefit, there may be a significant placebo effect to take into account—an astonishing 82 percent, according to a data analysis from the University of Connecticut. The researchers speculate that if these two findings are cumulative, the drug-specific benefit for the user may be "clinically negligible."
The percentage of SSRI users who take a hit to the libido, however, may be significant. "I think we can be confident that the majority will be affected by sexual side effects, perhaps somewhere between 50 and 70 percent of people who take them," says Bahrick. In a recent Iranian study, researchers concluded that sexual side effects affected 75 percent of people using SSRIs. Another study found the effect as high as 98 percent. It's a nearly perfect score for exactly the wrong thing.
If you are slack-jawed at this slack-penis (or vague-vagina) effect, it's probably because until recently, the labels on these drugs have reported a much lower risk. According to research by Bahrick, many of the SSRI package inserts even acknowledge that the sexual-dysfunction side effects reported in clinical trials, affecting 2 to 16 percent of users, may be an underestimation. How does 16 percent jump to 70 percent? In the initial clinical trials, the patients were not directly questioned about their sexual functioning. They were supposed to volunteer the embarrassing, confusing fact that they seemed to have been having lame sex an awful lot lately.
Kara (not her real name), a 22-year-old student in Washington state, was prescribed Cymbalta at age 18 for depression. She later took Zyprexa, Lexapro, Remeron, Pristiq, and then Prozac. She first noticed an effect while on Lexapro, when she masturbated "and had the weakest orgasm ever," and "total numbness in my vagina." Her emotional connection to lovers had been broken as well. "I had two long-term boyfriends that I really loved," she says. "As soon as I started taking Lexapro, there was this marked decrease in my ability to feel love for them and connection to them."
Bahrick thinks the effects on women don't receive enough attention. "With men it's easier to assess. A man who can no longer achieve an erection can't hide that fact from his partner, but a woman's loss of sexual functioning is less overt—she can choose to give pleasure even if she's not capable of receiving pleasure.
That might be acceptable in the short run, but it can wear thin over time."
As Kara says, "I don't know if I'm capable of falling in love anymore. The function isn't there. As for sex, I can't feel anything and just lie there like a sex doll. That's no fun for me."
That numbing effect happened to a man I'll call Rob, a real estate property manager who went on Lexapro for a lifelong case of dour outlook. Now, at 41, he remembers that he'd have been overjoyed to accept his lousy mood if he could have regained his libido when he quit the drug. When offered the med, "I was, like, 'Why not, what have I got to lose?'" he says. Lots, as it turned out. "For about a year it worked really well," he recalls. Sure, his libido ebbed, but at first he didn't mind. "Honestly, it was helpful, because I was so oversexed before then," he says.
But after a year the drug stopped working, so Rob decided to quit taking it. When he did, he discovered that his sexual function remained on pause—for five years. Once, in his first return to the bedroom with a woman he liked, he found himself struggling to reach half-mast. When it became clear that he couldn't perform, "she very cheerily got up and said she was going to go sleep in the guest bedroom," he says. "She'd left to go finish on her own, and I remember lying there thinking, 'Wow, how bad has my life become?'"
"There's a proportion of people for whom the change seems to be permanent," says David Healy, M.D., the author of Pharmageddon and founder of the drug side-effects database Reports of post-SSRI sexual disorder (PSSD, for short) are becoming more common, and the condition is being reported in medical journals. Prozac now carries the following ominous warning: "Symptoms of sexual dysfunction occasionally persist after discontinuation of fluoxetine treatment."
Thankfully, PSSD isn't the norm. Katherine Sharpe's desire peaked whenever she missed her pill, and Rob is now in a happy relationship. In case you might be wondering, I've shed my snowmobile boots in the bedroom. But terrible questions remain: How can one class of drugs turn off so many important pleasure zones? How can they diminish one of the most essential aspects of being human?
As it happens, the chemicals that throttle lust are the same ones that make life enjoyable. Antidepressants may interfere with nitric oxide, a blood molecule that relaxes smooth muscle and triggers the engorging of blood vessels in the penis, nipples, and clitoris during sex. The drugs also affect the way you think, feel, and relate to others. By raising serotonin, SSRIs overload receptors designed to keep dopamine activity high. That means less dopamine between neurons that serve as reward pathways of the brain. It is this neurotransmitter that makes possible thoughts like I want her, I need her, and even I love her. Depleting dopamine might distort, delay, or doom relationships.
The effect has a clinical name: emotional blunting. We have known since the late 1980s that antidepressants (and antipsychotics like Seroquel, Zyprexa, Abilify, and Risperdal) can induce apathy and indifference. Emotional blunting can be helpful in reducing feelings of sadness in depression, or fear and anxiety. But blunting also diminishes the kind of positive emotions you need to make a genuine connection with a romantic partner.
In one of the earliest accounts of emotional blunting, in the British Journal of Psychiatry in 2009, researchers at the University of Oxford, England, reported on SSRI effects in 38 users. The scientists found that "some participants felt reduced love or affection toward others and, in particular, reduced attraction toward their partner." They also discovered that SSRI use may cause "emotional detachment from other people, and reduced concern for other people's needs." Users of SSRIs can also be sloppier gauges of their own errors in judgment.
For instance, after only a week on the drug Celexa, even people who aren't depressed become less competent at detecting negative emotions in facial images, another Oxford study found. The evolutionary biologist Helen Fisher, Ph.D., who has written about the impact of SSRIs on relationships, notes: "When it comes to love and attachment, you want all your natural abilities in place. You don't want them blunted or altered."
Fisher, who has used fMRI scans to identify brain systems associated with desire, romantic love, and emotional attachment, is troubled about blunting among people who are not suffering from severe, chronic depression.
"It's one thing to lose the sex drive. But when you have sex it drives up testosterone, and more testosterone makes you want to have more sex, and having sex stimulates the genitals, and stimulating the genitals drives up the dopamine system, and that is needed to push yourself over the threshold and into falling in love," says Fisher. Orgasms also drive up oxytocin and vasopressin, she explains, "and that helps give you feelings of emotional attachment."
According to Lauren Starr, a spokeswoman for Pfizer, which manufactures Zoloft and Effexor, "Depressive and anxiety disorders, with or without treatment, can be associated with the emergence of adverse events such as sexual dysfunction." (The makers of Cymbalta and Lexapro declined to comment for this article. The maker of Paxil passed along a link to the drug's prescribing information.)
"Diminished sex drive really isn't a symptom of mild depression," says Stuart Shipko, M.D., a psychiatrist based in Pasadena, California. "However, diminished sex drive afflicts two-thirds of people who are prescribed an antidepressant. The sexual dysfunction caused by the drugs is much worse than sexual dysfunction from depression."
After eight years on antidepressants, Sharpe stopped at age 26. She felt that she was in the wrong phase of life to be foggy about how she felt. "College is a time of figuring out who you are, what kind of a path you want to put yourself on, and how you feel about things," she says. "One of the bad things about the overdiagnosis of young people is that it says the way you feel is a mistake, a product of an illness."
It's also a period when young people traditionally look for mates. "We're living in this time when the 20s have become a time of intense independence. Instead of partnering with someone in college, more and more people are living with friends and delaying settling down," Sharpe says. "I wonder if being mildly depressed, of having an acute sense of your need for comfort, keeps you in a relationship. If antidepressants give you a way to be on your own, they support this independent, self-centered social lifestyle," she says.
But there's a cost, says Fisher. "This game of love really matters during the reproductive years. We've evolved an enormous number of brain mechanisms to choose the partners we want. If you don't feel anything for anyone and go from one hookup to another, you will keep disappointing potential partners."
Plus, you may just miss your chance at the right one. "If you don't have any sex drive or can't feel any emotion," Fisher says, "how are you going to respond to the cute girl in algebra class or at the gym? These drugs are not a free ride."
submitted by PSSD_Kara to u/PSSD_Kara [link] [comments]

2019.12.23 05:49 Lukemage Growing up with an Insane, Entitled mother - Extended - Part 2

In mid February my grandfather died, and my mom shut down contact with us for 2-3 months.
She opened a custody case from a [Different State]( ) and sued my dad for custody of myself and my sisters. You can imagine how well this went over once the two judges did connect. She did manage to argue for getting visitation for holidays during the summer and over Christmas.
The visit over the summer was very strange, and I am sorry to say I don't remember much of it. By this point I was still on the dosage schedule, and was taking 100mg morning/night. Dr. Moreau was still pushing for me to follow the increased dosage, and seeing me each week. A new therapist, Dr. Stupid, documented in her notes that I wasn't acting like a normal 12 year old, and was clearly depressed in some serious way. This only fueled Dr. Moreau further.
8th grade was kinda .... strange, and once a different doctor saw the dosages I was on, he was astonished that I hadn't had either suffered a psychotic break, or died of liver failure. Being on 5 times the adult dosage shocked him, and it took me almost 2 months to clear it from my system, where he discovered: Surprise! I wasn't depressed at all.... Dr. Moreau had his license pulled when my dad found out he was giving me 5-6 times the ADULT dosage, the resulting investigation also sent him to prison, but for other reasons (yet again, a separate story).
Unfortunately my mom was able to use this as an attack on my dad, since he had had custody of me while I was on the highest dosage, and Dr. Stupid was, well, Stupid..... Thus she was able to successfully petition to regain custody of me, but only after a trial period where I lived with a consenting neutral party: My mom's eldest brother, let's call him Dave.
I lived with Dave, Dave's wife, and Dave's son for a year and a half, and then my mom was able to get me to move in with her. During that time my mom decided to embark on a new career as a truck driver.
My mom rented a three bedroom house in the small town she grew up in, and I moved in. The house was a decent size, two stories, and wasn't anything particularly special honestly. My mom converted one of the second floor bedrooms into a fabric storage room, and the other became her bedroom. I got the bedroom on the first floor.
I lived with Dave's family for the last half of 8th grade and 9th grade. I started living with my mom just before 10th grade. This resulted in a rather significant shift in my routine, but I coped.
My mom's job at the time had her on the road 12 days out of every 15, and had her home for maybe 50-60 hours consecutively. This resulted in my mom not really being around for 10th grade, and coincidentally, a rather important period in my life. Remember the Paxil? Yeah, it had more side effects that just placing me in a stupor for nearly a year, it also delayed puberty by nearly 2 years, which hit the summer before 10th grade. Around this time I also started to realize that I wasn't really attracted to girls, and had a rather serious crush on Dave's Son's best friend. With my mom not around however, and another brother of my mom's having a huge blowup argument with his wife over his son coming out gay and my uncle doing something VERY MUCH NOT OKAY(this is a totally separate story), I decided to hide everything from my family, for fear of the same reaction.
Nevertheless, I was a fairly reserved high school kid, but I am BIG. By 10th grade I was 6'1" and over 220lbs, I drew attention from a football coach and the wrestling coach, both of which pushed for me to tryout. I have little interest in team sports, and even less interest in proving that I am "the best" just for the sake of it, thus I decline their offers every time, but they were persistent. This attracted attention from several prominent members of those teams, who saw me as either competition, or more likely, the favorite of their coach. I tried to explain this to my mom, and even to Dave's wife who was a teacher at the high school, but no one seemed to get my disinterest, all refused to help. I won't go into all the details, but I got into a few fights, ruined the sports career of 3-4 guys, and this only compounded to the stress I was under.
The school I went to was Very homophobic. Anyone who was even suspected of being gay was harassed, bullied, and often assaulted. This came to a head in November of 10th grade, when I had to forcefully reject a girl. I claimed my mom didn't want me dating, and cited some of the "rules" she had tried to influence Becky with when she was in high school(basically abstinence). This didn't work as intended, and the next day I was in another fight, only this time because "why would you not want a blonde for a girlfriend?" This was the first fight that a teacher got involved in, and he walked in right after I yanked a guy's arm out of it's socket. My mom was called, I got screamed at(not for fighting, but for seriously injuring someone???), but a witness confirmed that it had been the other guy who instigated it, while his 2 buds tried to keep me from leaving. I still was grounded for the rest of the month.
Now, my mom was strange when it came to discipline when I was in high school. Since she wasn't around much, she wanted me to call her daily, and to write a journal of what I did. Okay, I didn't do much. But what the REAL punishment was her not coming home from work for nearly 3 weeks. The house was running low on food as a result, and I was spending my own money for lunches at school. My mom however, proceeded to sleep for nearly 24 hours straight, then play solitaire for another whole day, before sleeping and leaving again. I mentioned over the phone several times, and in person, that the house needed groceries but she always responded with "when I've slept/finished this game/finished my coffee/etc." After she left, I took an inventory of the house, and called my aunt, Dave's wife. She showed up 2 hours later with a load of groceries and said she had called my mom, tried to explain my situation, and my mom had hung up on her. I also repaid her for the groceries with my own money.
I'd like to say that my mom got the message, but unfortunately, she didn't. I had to call my Aunt twice more before 10th grade ended for similar reasons. I'd have gone to the store myself, but it was nearly 5 miles away in a straight line, and in the middle of December in the Midwest, in a small town with no bus services, no taxis.
Since I didn't do any extracurricular activities though the school, I instead volunteered at the library a few blocks from my house. This rolled into a part time job, mostly re-shelving, helping maintain the meeting/learning room schedules, and fixing the computers. This was pretty much on a "whenever needed" basis, or whenever they called, but usually 10-15 hours a week. My mom HATED this. She felt it harmed my school work(it didn't), and was only making me less responsible. She would steal my paychecks if she found them, but fortunately there was a way to get direct deposit going. (Unfortunately, this didn't stop her)
My mom continued to work roughly 12 days out of 15 for the rest of the 10th grade. That summer I had a summer job as a lifeguard for the high school aquatic center, and actually made a decent amount of money from this.
11th grade was a mess, and I've posted about why I left previously, but what made that possible was the nice little nest egg I'd saved up to that point. When I dropped out of high school, got my GED and started community college courses, my mom completely lost it. So I moved out, with the help of my best friend's dad (retired career US Navy NCO) who took no nonsense from anyone, liked me, and instantly hated my mom. I bought a fixer upper house a few miles away from hers(actually it was a short sale, and had been a meth lab, vacant for over a year, but it was fun to fix up) and never told her where I lived for a couple of years. I significantly cut off interacting with her in person, and only ever really spoke with her on the phone for much of that time. Fast forward almost 2 years.
In that time, Brother was now engaged, and getting married. It's a few months before my 18th birthday, and I decide to go along. My mom books the plane tickets, and insists I ride with her. Not 10 minutes into the car ride she blurts out "so, no girlfriend. I always knew you were gay." Thus ensued one of the SINGLE most UNCOMFORTABLE car rides anyone could have imagined, as my mom began to try giving me intimate advice, including details about my own father. This turned out to be my mom's way of extending an olive branch. Unfortunately, it wasn't real. Brother met us at the airport back in California, and mom just casually drops that I'm gay to him while he's driving, and then to his future wife when at the house, and then again to Lisa and her husband in the hotel lobby, and then to Rebecca in the hotel room...... Finally Donna walks up to her, uses one of her no-nonsense, deadpan flat tones, and says "hey mom, perhaps you shouldn't go around announcing someone's private details like a town gossip."
It was downright Hilarious to watch my mom's head go through realization that she's been talked back to, put in her place, delivered sage advice from a 16 year old, and called out in front of all 6 of her kids. The short circuit in her head was audible to everyone in the hotel room. Her logic, thought process, insanity, temporary loss or otherwise, it doesn't matter. The next thing she does is grab her hard shell carry on bag and swing it around at Donna.
Funnily enough, she missed. Donna was maybe 4 feet away, and mom somehow missed her completely. The bag swung past Donna's chest, then the handle slipped, and it went flying right into my groin.
And that is how I missed Brother's wedding, sitting on the bed in the hotel room, with ice in my lap. My mom didn't know, but I had a staph infection at the time(thanks Acne), with a sore in my groin, she popped it..... My mom was ushered out of the hotel room by Lisa and Becky, and somehow managed to "blackout" the 10-15 minutes or so involving the conversation in the hotel room. Then she tried to talk her way past Donna into the room, but that wasn't going to happen. I changed my flight and flew back separately from my mom, that scene was the last straw for me.
I continued living as I had been and communicating very little with my mom at all. I knew that she was trying to get a job working as a contractor in Iraq. She closed her house, and put everything into storage, the week of my 18th Birthday. Up until that point, I had only been attending classes online and part time, but with my 18th birthday approaching, I started to look into options for expanding my school opportunities. Chief among them was a college fund my grandfather, my mom's father, had set up for me when I was born. He very Strongly believed in education, and for each of his grandchildren he put together a modest college fund. By the time I was 18 mine was a little over $20,000. I had intended to use it for covering some tuition so I'd have to open smallefewer student loans. My 18th Birthday rolls around, I walk to the bank that managed the fund, and am informed that it has been cashed out already. I am also informed that the two student credit cards I'd applied for were already maxed out. I was stunned, and demanded to know how all of these things had happened.
Three guesses how? Yeah..... She did. My mom had cleared out the college fund, and used a funds transfer to move the balance on the two cards over to another card in her name. She had done all of this the day before my birthday, and had used MY personal information to do it over the phone. I was understandably pissed. I confronted her in my grandmother's living room, and the shouting match we had very nearly leveled the house. Her justification included many platitudes that, honestly, are some of the most entitled things that I have ever year anyone ever say:
I finally left, walking until about midnight to get home. I spoke with the bank the next day, and did everything I could to file fraud claims against my mom's actions. This unfortunately didn't do much, as when they issued a determination, my mom was already out of the country.
I moved on, got a more steady job, and began saving up. My mom may have screwed me with my short term plans, but I was still determined to continue forward.
A year and a half later, I'm playing World of Warcraft in my house, and take a break to make some food. I go into the kitchen, start making some pasta, when I heard the front door open. Now, I had that door locked, but it opened, then clicked closed, just like someone had used a key. I saw my normal key on it's hook by the back door, and the only other key was in the false bottom of the hanging pot on the front porch. My best friend knew it was there, and his wife, so I figured it was them and I'd just missed their call. I walk into the living room and stop dead, it's my mom.
She had "invited" herself to stay with me while she looked around to find a new house. I tried to refuse, but then my grandmother walked in. Now everything clicked, I had shared my address with my grandmother, and that there was a spare key, just not where it was. My grandmother said my mom couldn't stay with her, and since I had a spare bedroom, it shouldn't be a problem for my mom to stay with me for a few weeks. I was livid, but I also knew that my grandmother couldn't have her stay at her house, a tree had smashed the roof earlier in the year and it was still being repaired. I grudgingly agreed, but only if she paid 100$ a week to rent the room. She agreed, and wrote me a check for the first 4 weeks.
She ended up staying only 3 weeks however, and while I was out riding my bike, I saw smoke from around where my house was, and started riding home. She had been sleeping when I left, but that had been hours earlier. I rounded the block just in time to see the fire department pulling the roof off my house as the entire structure collapsed, to keep it from damaging my neighbors house.
Standing around watching were my neighbors, including Martha, the super amazing retired woman across the street. Martha saw me and instantly began saying she was glad I was safe, that they had thought I was inside. I asked what had happened, barely controlling myself, and Martha said she had seen smoke coming from my roof and called 911. A member of the fire department arrived, and informed me that they had removed a woman from the house, who insisted she could put the fire out herself .... with a mixing bowl filled with water. I just stared. They had transported my mom to the hospital.
I went to the hospital (thanks to Dave's wife giving me a ride) and found my mom in the ER in restraints, waiting for a psych consult. She had some smoke inhalation, and a BAC of 0.19. The psych consult came by, had her sedated and admitted for a 72hr watch, because she was so severely intoxicated. I got my moms part of the story from the Psych doctor(I needed a statement for the fire dept.):
The fire department had determined that the fire had spread very quickly through the dry roof, and if my mom had returned to the room, she likely would have found it entirely on fire.
PSA: Seriously, fire is no freaking joke! Don't mess with that Sh!t.
Its at this point I refused to see my mom ever again. I opened up a PO Box, I used what few funds I had to move to a nearby city, and stayed closer to school. I also explored some legal options, but that wasn't going to get me anywhere. The best legal advice I had was that I shouldn't have ever let my mom stay with me to begin with.
I continued to argue with her about the fire and money and everything for about 8 months, before just throwing my hands up and blocking her.
I'd moved back to California, and was living with my dad while finishing off my degree, and Rebecca was graduating high school. My mom was invited, and because of the bad blood, I didn't see her the entire ceremony, however what she did I heard via my father:
I did go to the restaurant however, but I sat with Brother.
My mom's scene at dinner kinda ruined the mood, but Rebecca has always had a .... rose tinted view of my mom, and brushed it off. Stepmom and Dad were PISSED however.
Mom drove down with Brother afterwards, and stayed with him for a week or so. This would become a semi-regular occurrence for about 2 years.
At this time my mom was sharing a house with Donna. Donna has her own list of complaints about this, but suffice to say, mom acted like the house was Hers, and drove Donna up the wall. Donna eventually kicked her out after about a year.
I didn't see her until last year. Rebecca was getting married, and all but Becky managed to attend. I intentionally didn't want to interact with her, but she wasn't going to have that.
I haven't seen my mom since Rebecca's wedding, and honestly, I've long since reached my limit with her.
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2019.12.19 01:24 kentuckyloglady Kratom has changed my life for the better after SSRI's

I took Paxil and Hydrozyzine for almost 5 years. I was always completely dissociated. I never knew where I was at, or what was going on. The world could have exploded and I wouldn't have cared. I thought depressants were supposed to make you feel the opposite but it didn't for me. I totaled my car in 2016 from being in a sedative state. I lost a job because I would call in everyday because I would sleep for around 17 hours a day. I slowly weaned myself over a time period of 6 months from both medications. I've been taking a gram of kratom a day now for almost 3 years and I'm finally back to my old self. I hadn't felt remotely decent in so long that I had forgot what it was like. Kratom has brought me out of the worst suicidal, depressive state I had ever been in. I received my GED in January of this year and have started community college. I just finished my first semester with being on the Deans List. Kratom has helped me in more ways than one. It has changed me from the negative and sad person I once was into the person I was long ago.
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2019.12.14 14:38 Leetis19 Dosages, results

I have recently started taking Kratom to discontinue Paxil, and also for pain, I have been taking a teaspoon 1 to 2 times per day. I have noticed some help with pain reduction, but I dont notice much if any euphoria or “feel good” affect So to speak. I have read that higher dosages have a sedating affect, which I DONT need. Should i be taking more? Thanks
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2019.10.12 02:50 stroke_bot siphac myricetin extralateral monosyllabically prediscontented benedicite noncarbonate

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